“Sicario” is a 2015 adventure thriller that realistically depicts the violence and complexities of the drug war along the U.S.-Mexico border. Its 2018 sequel, “Sicario: Day of the Soldado,” shows an escalation where drug cartels begin trafficking terrorists into the U.S. The third installment, “Sicario: Capos,” is still in development.

We’re not sure what the story will look like, but if the “Sicario” team wants to show some real greed and inhumanity, the bad guys this time should be Big Pharma.

That’s the newest chapter of the war on drugs, where the best organized cartel in world history — Big Pharma — is exploiting the Biden administration’s chaos at the border. Namely, they’re buying blood from desperate migrants.

Big Pharma has been encouraging Mexican nationals to cross the border and sell their plasma, which violates their visas. Millions of liters a year, up to 10% of the blood plasma collected in the U.S., comes from Mexicans on business and tourist visas. In a unique take on the “working vacation,” the act of selling tourist plasma can be quite lucrative: Thousands of Mexicans cross the border to donate plasma as often as twice a week, earning as much as $400 per month. Donors can even earn “buddy bonuses” for bringing a friend along with.

The American Red Cross recommends you not donate plasma more than once every 28 days — or about 12 times annually — but some Mexicans are donating more than 70 times per year!

Indeed, the practice has become so lucrative that plasma centers have been placed strategically along the U.S.-Mexico border, where more than 50 Spanish-friendly collection centers have cropped up in recent years. According to one court filing, border centers bring in 31% more than the average centers nationwide.

One of the reasons this fresh new branch of the drug trade has grown is because it’s been illegal to sell plasma in Mexico since 1987. (So is even just advertising that, but social media can cross borders effortlessly.) So while Americans have been buying illegal drugs from Mexico, Mexicans are selling illegal blood.

If taking advantage of poor people to collect blood seems ghoulish, that’s only because it is. It is also reason No. 925 — contrary to all of the Democrats’ self-righteous, self-motivated sermonizing of the last eight years — why an open southern border is immoral.

Also, we’re not sure about how much else Big Pharma might exploit people with no legal protections, but we do know the FDA and the New England Journal of Medicine wants to make sure they have as diverse as possible populations for clinical trials.

Corporate America’s behavior in abandoning conservatives has been quite a quandary. After Republicans carrying water for them for decades, forgive the mixed metaphor, Big Business has been happy to throw us under the bus, whether it’s selling out to the Chinese or racial discrimination diversity efforts like Disney’s.

Big Pharma has also been walking lockstep on amnesty schemes with so-called progressives’ attempt to fundamentally transform America with mass migration. Eli Lilly supports “a pathway to citizenship in the United States for Dreamers.” Johnson & Johnson also supports “comprehensive immigration” — the newspeak term for mass migration. Both companies have given scholarships to Deferred Action for Childhood Arrivals (DACA) children at the expense of scholarships that could have gone to the children of U.S. citizens.

Moreover, in what might be the corporate drug dealer equivalent of “the first one’s free,” some pharmaceuticals provide direct discounts on medications for illegal immigrants, including Pfizer, AbbVie and Gilead, and GlaxoSmithKline.

Big Pharma throws more money at Democrats (for now), but do they really think that will win the goodwill of, say, a President Ocasio-Cortez? As for Republicans, take notes and don’t fall for any tricks down the road these open borders pharmaceutical companies will try to pull on you.

While the most valuable commodity shipped across the border 20 years ago was cocaine, as Josh Brolin explains in “Day of the Soldado,” nowadays it’s people. Or at least the blood they bring with them.

Jared Whitley has worked in the U.S. Senate and White House. He has an MBA from Hult Business School in Dubai. Recently, the Top of the Rockies competition named him the best columnist in the Intermountain West.